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Practice problem

Missense Mutation — Definition & Examples

By Gabi Slizewska

A certain mutation in DNA causes the protein hemoglobin to change its shape. This abnormality results in sickle cell anemia. The DNA sequence is shown below.

Normal hemoglobin contains the codon CTT which corresponds to the amino acid Glu. Mutated hemoglobin contains the sequence CAT which corresponds to the amino acid Val.

Image source: By Thomas Samuel for ACC-BioinnovationLab CC BY 2.0, via Wikimedia Commons

What type of point mutation causes sickle cell anemia?

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Type a concept, like “slope” or “photosynthesis”.

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