Genetic Mutations — Overview & Allele Frequency

DNA is transcribed into RNA, and RNA is translated into proteins. Proteins are built with building blocks called amino acids. RNA orders and connects amino acids by assigning specific amino acids to 3 nucleotide long segments. For example, a bit of RNA that reads AUG calls for a methionine, UCG calls for a serine, and so on.

Mutations cause changes in the protein by changing what amino acids the RNA calls for. Changing an AUG to ACG would give you threonine instead of methionine.

Using this knowledge, which mutation would cause the least amount of change in the final protein?