The image shows a brown mule carrying a leather pack. Around the mule is a trailer, another mule, and a green truck. A man in a cowboy hat and a yellow jacket is carrying a leather pack away from the mule.

Mule packer on Klamath National Forest by Pacific Southwest Region 5, CC by 2.0 via Flickr

When a horse mother and a donkey father have an offspring, it is referred to as a mule. A horse has 64 chromosomes and a donkey has 62. When a mule's sex cells try to undergo meiosis, the inherited chromosomes are unable to properly distribute. What method of reproductive isolation is this?

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