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Practice problem

Missense Mutation — Definition & Examples

By Gabi Slizewska

A list of codons and the amino acids they code for. UUU and UUC code for Phe. UUA, UUG, CUU, CUC, CUA, and CUG code for Leu. AUU, AUC, and AUA code for Ile. AUG codes for Met. GUU, GUC, GUA, and GUG code for Val. UCU, UCC, UCA, UCG, AGU, and AGC code for Ser. CCU, CCC, CCA, and CCG code for Pro. ACU, ACC, ACA, and ACG code for Thr. GCU, GCC, GCA, and GCG code for Ala. UAU and UAC code for Tyr. UAA, UAG, and UGA code for Stop. CAU and CAC code for His. CAA and CAG code for Gln. AAU and AAC code for Asn. AAA and AAG code for Lys. GAU and GAC code for Asp. GAA and GAG code for Glu. UGU and UGC code for Cys. UGG codes for Trp. CGU, CGC, CGA, and CGG code for Arg. AGU, AGC, AGA, and AGG code for Arg. GGU, GGC, GGA, and GGG codes for Gly.

In a particular DNA sequence, there is a mutation in the codon which would normally code for arginine (Arg). The codon now has a missense mutation. In which base of the codon is the mutation most likely to be?