Substitution (DNA Mutation) — Definition & Examples
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- Substitution Mutations A substitution mutation is when one nucleotide is swapped out for another. These types of mutations are the least dangerous of all the DNA mutations. That…
By Aaron Lauer, Deena Hauze, Alex Federspiel, Mario Janakis, Caroline K
- Substitution Mutations A substitution mutation occurs when specific bases (A, T, C or G) in a gene are swapped for different ones. This type of mutation doesn't cause a differen…
By Samantha Broders, Deena Hauze, Alex Federspiel, Mario Janakis, Caroline K
- What Are Substitution Mutations? Substitution mutations are exactly what you would expect—a nucleobase is swapped with another in a DNA sequence. This is kinda like having a sub…
By Deena Hauze, Alex Federspiel, Mario Janakis, Caroline K
- (Video) Consequences of a Base Substitution Mutation by Stephanie Castle In this video, Stephanie Castle explains how a simple substitution mutation results in a common genetic …
By Gabi Slizewska, Mario Janakis
Problems 20
- An original DNA sequence is ATT GCA\text{ATT GCA}ATT GCA but after replication, it is ATT CCA\text{ATT CCA}ATT CCA. What kind of mutation happened?
- What is it called when a mutation causes a protein to be terminated early?
- Why do substitution mutations often not change the amino acid sequence at all?
- What sort of mutation occurs when one nucleotide is swapped for another?
- When DNA is being replicated, a complementary strand of mRNA is made. Which of the following options shows a substitution mutation on the mRNA? The original DNA sequence is: TAC…
- Which of the following is not a point mutation caused by a substitution mutation?
- When is a substitution mutation the most damaging?
- There is a single substitution mutation in a codon which typically makes valine (Val). Using the genetic code above, predict which of the following could be the resulting amino …
- A codon is changed from UAC\text{UAC}UAC, which codes for the amino acid tyrosine, to UAG\text{UAG}UAG, a stop codon. Select all types of mutations that characterize this change.
- Which of the following is a substitution mutation? Select any that apply.
- Which of the following can cause a nonsense mutation?
- Which of the following can cause a missense mutation?
- Ogden syndrome is a genetic disorder which causes premature aging in infants. It is caused when the codon for amino acid serine (TGT) is modified to code for proline (TGC). Whic…
- One of the C\text{C}C bases in a DNA sequence is changed to an A\text{A}A base. What kind of mutation is this?
- There is a substitution mutation in the codon AAG\text{AAG}AAG. Which of the following could have happened?
- A DNA sequence codes for amino acids Gly-Asn-His-Ser-Arg. After the sequence is mutated it codes for Gly-Asn-Glu-Ser-Arg. What kind of mutation is this?
- A substitution mutation can change the order of amino acids that a DNA sequence codes for. How severe the effects are depends largely on the chemical properties of amino acids. …
- Imagine you are taking a scantron test and you are on problem 1. Which of the following options is most like a substitution mutation?
- The point mutation responsible for sickle cell anemia changes a single amino acid from Glutamine to Valine. What type of mutation is this?
- The point mutation responsible for sickle cell anemia changes a single amino acid from Glutamine (Glutamic acid) to Valine. Why might this one amino acid change cause the negati…